Detailed HPLC Determination Method for Sodium Formate (Complete Protocol)
Sodium formate is an important chemical raw material and intermediate, so its purity analysis is crucial for quality control and scientific research. High-performance liquid chromatography (HPLC) is one of the preferred methods for determining sodium formate content and related impurities, thanks to its high separation efficiency, good reproducibility, and sensitivity.
Method Principle
This method is based on the principle of reversed-phase liquid chromatography. As a highly polar ionic compound, sodium formate has weak retention on common reversed-phase C18 columns. By adding buffer salts to the mobile phase and adjusting the system’s pH and ionic strength, the dissociation state of sodium formate can be controlled, thereby improving its retention behavior and separation selectivity on the stationary phase. The addition of organic solvents is mainly used to adjust elution strength, achieving effective separation between the target compound and impurities, followed by quantitative analysis using a UV detector at a specific wavelength.

Sodium Formate from Shandong Pulisi Chemical Co., Ltd.     info@pulisichem.cn

Shandong Pulisi Chemical Co., Ltd. is a professional manufacturer and supplier of high-quality sodium formate, strategically located in Zibo, Shandong, a key chemical industry hub in China. Our sodium formate is produced using an optimized coke-based synthesis process, ensuring consistent purity, low impurity levels, and stable performance for a wide range of industrial applications.

Our product portfolio includes both industrial-grade and high-purity sodium formate, tailored for use in leather tanning, textile dyeing, oil drilling, concrete additives, and pharmaceutical intermediates. Rigorous quality control is implemented at every stage, from raw material sourcing and reaction monitoring to HPLC-based purity testing, ensuring compliance with international standards and customer specifications.
With reliable production capacity and flexible supply chain solutions, we support global clients with prompt delivery, competitive pricing, and dedicated technical support. Our sodium formate has earned recognition for its consistent quality and performance, making us a trusted partner in the chemical industry worldwide.

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