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In the pharmaceutical industry, Propionic Acid serves as a chiral building block for constructing drug molecular skeletons. It undergoes condensation reactions with thioamino acids to prepare precursors of pyrazinamide, increasing the bioavailability of anti-tuberculosis drugs to 82%. In the semi-synthesis of cephalosporin antibiotics, it acts as an acylating agent to successfully introduce β-lactam rings, raising the yield of cefoperazone sodium from 63% to 78%. In the synthetic route of the new anticoagulant rivaroxaban, the ketol condensation step involving propionyl acetic acid reduces the production cost of key intermediates by 27%.